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ER-27319

Catalog No. T78641 CAS 201010-95-9

ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory concentration (IC50) of 10 µM, this compound suppresses the release of allergic mediators from human and rat mast cells triggered by antigens, making it useful for allergy research [1] [2].

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ER-27319, CAS 201010-95-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description

In vitro

ER-27319 (24 h) inhibits antigen-induced myo-inositol phosphate generation, arachidonic acid release, and histamine and tumor necrosis factor α secretion in RBL-2H3 cells, rat peritoneal, and human cultured mast cells, with an IC50 value of approximately 10 μM [1]. ER-27319 (10-30 μM, 10 min) selectively inhibits the tyrosine phosphorylation of SYK induced by immunoreceptor tyrosine activation motif upon FcεRI γ phosphorylation [1]. ER-27319 (up to 100 μM, 60 min) does not inhibit ZAP-70 tyrosine phosphorylation triggered by CD3 stimulation in Jurkat cells [1]. ER-27319 (100 μM, 10 min) suppresses the tyrosine phosphorylation of two proteins (38, 70 kD) and reduces the tyrosine phosphorylation of two other proteins (62, 80 kD) in canine cutaneous mastocytoma cells challenged with anti-IgG [2].

Molecular Weight	370.4
Formula	C20H22N2O5
CAS No.	201010-95-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ER-27319 201010-95-9 Angiogenesis Tyrosine Kinase/Adaptors Syk inhibitor inhibit

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