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ML402

Name: ML402
Brand: TargetMol
SKU: T16109
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16109Cas No. 298684-44-3

Alias ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide

ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.

ML402

🥰Excellent

Purity: 99.71%

Catalog No. T16109Alias ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamideCas No. 298684-44-3

ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$73	In Stock
25 mg	$148	In Stock
50 mg	$238	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Batch Information

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Purity:99.71%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
In vitro	ML402 targets TRAAK with EC50 of 13.6 μM[1].
Synonyms	ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide

Chemical Properties

Molecular Weight	295.78
Formula	C₁₄H₁₄ClNO₂S
Cas No.	298684-44-3
Smiles	Cc1cc(Cl)ccc1OCCNC(=O)c1cccs1
Relative Density.	1.272 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (321.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3809 mL	16.9045 mL	33.8089 mL	169.0446 mL
5 mM	0.6762 mL	3.3809 mL	6.7618 mL	33.8089 mL
10 mM	0.3381 mL	1.6904 mL	3.3809 mL	16.9045 mL
20 mM	0.1690 mL	0.8452 mL	1.6904 mL	8.4522 mL
50 mM	0.0676 mL	0.3381 mL	0.6762 mL	3.3809 mL
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc