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ML402

Name: ML402
Brand: TargetMol
SKU: T16109
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16109Cas No. 298684-44-3

Alias ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide

ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.

ML402

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Purity: 99.71%

Catalog No. T16109Alias ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamideCas No. 298684-44-3

ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	-	In Stock
10 mg	$73	-	In Stock
25 mg	$148	-	In Stock
50 mg	$238	-	In Stock
100 mg	$353	-	In Stock
200 mg	$493	-	In Stock
1 mL x 10 mM (in DMSO)	$47	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
In vitro	ML402 targets TRAAK with EC50 of 13.6 μM[1].
Synonyms	ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide

Chemical Properties

Molecular Weight	295.78
Formula	C₁₄H₁₄ClNO₂S
Cas No.	298684-44-3
Smiles	Cc1cc(Cl)ccc1OCCNC(=O)c1cccs1
Relative Density.	1.272 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (321.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3809 mL	16.9045 mL	33.8089 mL	169.0446 mL
5 mM	0.6762 mL	3.3809 mL	6.7618 mL	33.8089 mL
10 mM	0.3381 mL	1.6904 mL	3.3809 mL	16.9045 mL
20 mM	0.1690 mL	0.8452 mL	1.6904 mL	8.4522 mL
50 mM	0.0676 mL	0.3381 mL	0.6762 mL	3.3809 mL
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc