ARUK2010489

Name: ARUK2010489
Brand: TargetMol
SKU: T212596
Rating: 4.5 (1 reviews)

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Catalog No. T212596

Alias ARUK-2010489, ARUK2010489, ARUK 2010489

ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease.

ARUK2010489

🥰Excellent

Catalog No. T212596Alias ARUK-2010489, ARUK2010489, ARUK 2010489

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Product Introduction

Bioactivity

Description	ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease.
Targets&IC50	CDK6:3.84 μM, NUAK1:8.7nM, CDK2:14.28 μM, CDK4:2.56 μM
In vitro	Method: Optimization of the CDK2 inhibitor NU6140 was performed to generate selective NUAK1 inhibitors, followed by pharmacokinetic and brain penetration studies in mice. Result: ARUK2010694 showed improved plasma half-life, while ARUK2010489 demonstrated high brain penetration (mouse Kp,u,ub = 2.29) and selective NUAK1 inhibition without CDK2 activity[1].
Synonyms	ARUK-2010489, ARUK2010489, ARUK 2010489

Chemical Properties

Molecular Weight	404.55
Formula	C₂₄H₃₂N₆
Smiles	CC(C)N1CCN(C2=CC=C(NC3=NC(CCC4CC4)=C(C=CN5)C5=N3)C=C2)CC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

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