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ARUK2010489
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Catalog No. T212596
Alias ARUK-2010489, ARUK2010489, ARUK 2010489
ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease.
ARUK2010489
😃Good
Catalog No. T212596Alias ARUK-2010489, ARUK2010489, ARUK 2010489
ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $290 | Inquiry | Inquiry | |
| 10 mg | $464 | Inquiry | Inquiry | |
| 25 mg | $929 | Inquiry | Inquiry | |
| 50 mg | $1,490 | Inquiry | Inquiry | |
| 100 mg | $2,240 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | ARUK2010489 (Compound 23) is a potent, selective, and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7, also exhibiting partial inhibitory activity against CDK2, CDK4, and CDK6 at micromolar concentrations, and it is applied in neurological disease research, including mechanistic studies related to Alzheimer’s disease. |
| Targets&IC50 | CDK4:2.56 μM, CDK2:14.28 μM, CDK6:3.84 μM, NUAK1:8.7nM |
| In vitro | Method: Optimization of the CDK2 inhibitor NU6140 was performed to generate selective NUAK1 inhibitors, followed by pharmacokinetic and brain penetration studies in mice. Result: ARUK2010694 showed improved plasma half-life, while ARUK2010489 demonstrated high brain penetration (mouse Kp,u,ub = 2.29) and selective NUAK1 inhibition without CDK2 activity[1]. |
| Synonyms | ARUK-2010489, ARUK2010489, ARUK 2010489 |
| Molecular Weight | 404.55 |
| Formula | C24H32N6 |
| Smiles | CC(C)N1CCN(C2=CC=C(NC3=NC(CCC4CC4)=C(C=CN5)C5=N3)C=C2)CC1 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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