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LEI-401

Name: LEI-401
Brand: TargetMol
SKU: T38001
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38001Cas No. 2393840-15-6

Alias LEI 401

LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.

LEI-401

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Purity: 99.79%

Catalog No. T38001Alias LEI 401Cas No. 2393840-15-6

Pack Size	Price	Availability	Quantity
1 mg	$52	In Stock

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Purity:99.79%

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Product Introduction

Bioactivity

Description	LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
Targets&IC50	NAPE-PLD:0.86 μM
In vitro	In HEK293T cells transfected with hNAPE-PLD, LEI-401 (0.04 - 20 μM; 30 minutes) dose-dependently reduces the labeling of NAPE-PLD, with an IC50 of 0.86 μM. LEI-401 decreases the levels of NAE in Neuro-2a cells but does not reduce them in NAPE-PLD KO cells[1].
In vivo	The in vivo pharmacokinetic profile of LEI-401 was evaluated in the plasma of C57BL/6J mice following intraperitoneal (i.p., 30 mg/kg), oral (p.o., 10 mg/kg), or intravenous (i.v., 1 mg/kg) administration. The results demonstrate that LEI-401 is an active NAPE-PLD inhibitor in vivo, indicating its suitability for studying the physiological role of NAPE-PLD[1].
Synonyms	LEI 401

Chemical Properties

Molecular Weight	421.54
Formula	C₂₄H₃₁N₅O₂
Cas No.	2393840-15-6
Smiles	O[C@H]1CCN(C1)c1cc(nc(n1)N1CCC[C@H](C1)c1ccccc1)C(=O)NCC1CC1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (189.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3723 mL	11.8613 mL	23.7225 mL	118.6127 mL
5 mM	0.4745 mL	2.3723 mL	4.7445 mL	23.7225 mL
10 mM	0.2372 mL	1.1861 mL	2.3723 mL	11.8613 mL
20 mM	0.1186 mL	0.5931 mL	1.1861 mL	5.9306 mL
50 mM	0.0474 mL	0.2372 mL	0.4745 mL	2.3723 mL
100 mM	0.0237 mL	0.1186 mL	0.2372 mL	1.1861 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc