Shopping Cart

Remove All
Your shopping cart is currently empty

HLCL-61 hydrochloride

Name: HLCL-61 hydrochloride
Brand: TargetMol
SKU: T6857
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6857Cas No. 1158279-20-9

Alias HLCL-61 HCL

HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

HLCL-61 hydrochloride

🥰Excellent

Purity: 99.95%

Catalog No. T6857Alias HLCL-61 HCLCas No. 1158279-20-9

HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$43	In Stock
25 mg	$73	In Stock
50 mg	$118	In Stock
100 mg	$223	In Stock
200 mg	$313	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.95%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
Targets&IC50	PRMT5:16.74 μM
In vitro	HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1].
Cell Research	CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference)
Synonyms	HLCL-61 HCL

Chemical Properties

Molecular Weight	380.91
Formula	C₂₃H₂₄N₂O·ClH
Cas No.	1158279-20-9
Smiles	Cl.CCn1c2ccccc2c2cc(CNCc3ccccc3OC)ccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (131.26 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 15 mg/mL (39.38 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6253 mL	13.1265 mL	26.2529 mL	131.2646 mL
5 mM	0.5251 mL	2.6253 mL	5.2506 mL	26.2529 mL
10 mM	0.2625 mL	1.3126 mL	2.6253 mL	13.1265 mL
20 mM	0.1313 mL	0.6563 mL	1.3126 mL	6.5632 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0525 mL	0.2625 mL	0.5251 mL	2.6253 mL
100 mM	0.0263 mL	0.1313 mL	0.2625 mL	1.3126 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc