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Zosuquidar

Name: Zosuquidar
Brand: TargetMol
SKU: T6018L
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6018LCas No. 167354-41-8

Alias RS33295-198, RS 33295-198, LY-335979, LY335979

Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity, inhibits tumor growth, significantly inhibits PD-L1 expression by triggering its autophagic degradation, and is used in the study of acute myeloid leukemia.

Zosuquidar

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Purity: 99.99%

Catalog No. T6018LAlias RS33295-198, RS 33295-198, LY-335979, LY335979Cas No. 167354-41-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$163	-	In Stock
10 mg	$245	-	In Stock
25 mg	$397	-	In Stock
50 mg	$597	-	In Stock
100 mg	$868	-	In Stock
200 mg	$1,190	-	In Stock
1 mL x 10 mM (in DMSO)	$189	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity, inhibits tumor growth, significantly inhibits PD-L1 expression by triggering its autophagic degradation, and is used in the study of acute myeloid leukemia.
In vitro	Zosuquidar (0.3 μM, treated for 48 hours) enhances the cytotoxic effect of DNR (P-glycoprotein substrate) in P-glycoprotein-active cell lines. [2] Zosuquidar (5-16 μM, treated for 72 hours) alone exhibited strong cytotoxicity in drug-sensitive cell lines and multidrug resistant (MDR) cell lines. [1]
In vivo	Intraperitoneal injection of 30, 10, 3, or 1 mg/kg Zosuquidar once daily for 5 days significantly prolonged subject survival. [1] Intraperitoneal injection of 30 mg/kg Zosuquidar once daily for 5 days observed a significant potentiation when combined with adriamycin (Doxorubicin). [1]
Synonyms	RS33295-198, RS 33295-198, LY-335979, LY335979

Chemical Properties

Molecular Weight	527.6
Formula	C₃₂H₃₁F₂N₃O₂
Cas No.	167354-41-8
Smiles	FC1(F)[C@]2([C@@]1(C=3C([C@@H](C=4C2=CC=CC4)N5CCN(C[C@H](COC=6C7=C(C=CC6)N=CC=C7)O)CC5)=CC=CC3)[H])[H]
Relative Density.	1.36 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (151.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8954 mL	9.4769 mL	18.9538 mL	94.7688 mL
5 mM	0.3791 mL	1.8954 mL	3.7908 mL	18.9538 mL
10 mM	0.1895 mL	0.9477 mL	1.8954 mL	9.4769 mL
20 mM	0.0948 mL	0.4738 mL	0.9477 mL	4.7384 mL
50 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8954 mL
100 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.9477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc