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3',4'-Dihydroxyflavonol (Synonyms: DiOHF)

Name: 3',4'-Dihydroxyflavonol
Brand: TargetMol
SKU: T14036
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14036 Copy Product Info

Purity: 99.41%

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3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant that reduces ROS and superoxide production in the mesenteric arteries of diabetic rats, increases total eNOS expression, and improves nitric oxide (NO) activity.

3',4'-Dihydroxyflavonol

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Catalog No. T14036

Synonyms DiOHF

Cas No. 6068-78-6

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Pack Size	Price	USA Stock	Global Stock
2 mg	$38	-	In Stock
5 mg	$60	-	In Stock
10 mg	$98	-	In Stock
25 mg	$213	-	In Stock
50 mg	$338	-	In Stock
1 mL x 10 mM (in DMSO)	$66	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.41%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant that reduces ROS and superoxide production in the mesenteric arteries of diabetic rats, increases total eNOS expression, and improves nitric oxide (NO) activity.
In vitro	3',4'-Dihydroxyflavonol (DiOHF) exhibits significant vascular protective effects under oxidative stress conditions, maintaining the biological activity of nitric oxide (NO) through multiple mechanisms. This compound can effectively alleviate the vasoconstrictive response of the tertiary branches of the rat mesenteric artery through Ca²⁺ desensitization, thereby reducing vascular permeability. At the same time, DiOHF significantly improves NO activity and endothelial function in pathological conditions such as diabetes by inhibiting Nox2-dependent superoxide production and preventing eNOS uncoupling. These synergistic effects make DiOHF a potential vascular function regulator, especially in pathological conditions with elevated reactive oxygen species levels, showing important therapeutic value. [1]
Synonyms	DiOHF

Chemical Properties

Molecular Weight	270.24
Formula	C₁₅H₁₀O₅
Cas No.	6068-78-6
Smiles	O=C1C(O)=C(OC=2C=CC=CC12)C=3C=CC(O)=C(O)C3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (370.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	185.0207 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL	18.5021 mL
20 mM	0.1850 mL	0.9251 mL	1.8502 mL	9.2510 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7004 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8502 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc