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Anti-PRSS3 Antibody (6K687) is a Rabbit antibody targeting PRSS3. Anti-PRSS3 Antibody (6K687) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $269 | 7-10 days |
Description | Anti-PRSS3 Antibody (6K687) is a Rabbit antibody targeting PRSS3. Anti-PRSS3 Antibody (6K687) can be used in ELISA. |
Alias | TRY4, TRY3, T9, RP11-176F3.3, PRSS4, protease, serine 3, MTG |
Ig Type | Monoclonal Rabbit IgG |
Clone | 6K687 |
Reactivity | Human |
Application | ELISA |
Recommended Dose | ELISA: 1:5000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Trypsin-3 / PRSS3 (rh Trypsin-3 / PRSS3; TMPY-01897; P35030-3; Met1-Ser247). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human Trypsin-3 / PRSS3 protein (TMPY-01897) |
Antigen Species | Human |
Biology Area | Serine Proteases and Regulators |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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