Aurora inhibitor 1

Name: Aurora inhibitor 1
Brand: TargetMol
SKU: T10412
Rating: 4.5 (1 reviews)

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Catalog No. T10412Cas No. 2227019-45-4

Aurora inhibitor 1 is a potent inhibitor of Aurora A and Aurora B kinases with IC50 values of ≤ 4 nM and ≤ 13 nM, respectively.

Aurora inhibitor 1

😃Good

Catalog No. T10412Cas No. 2227019-45-4

Aurora inhibitor 1 is a potent inhibitor of Aurora A and Aurora B kinases with IC50 values of ≤ 4 nM and ≤ 13 nM, respectively.

Pack Size	Price	Availability
25 mg	$3,130	3-6 months
50 mg	$4,610	3-6 months
100 mg	$5,730	3-6 months

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Product Introduction

Bioactivity

Description	Aurora inhibitor 1 is a potent inhibitor of Aurora A and Aurora B kinases with IC50 values of ≤ 4 nM and ≤ 13 nM, respectively.
Targets&IC50	Aurora B:13 nM, Aurora A:4 nM
In vitro	Aurora inhibitor 1 (Compound 16) demonstrates Kd values of 0.01 nM for both Aurora A and Aurora B kinases.
In vivo	In vivo efficacy in a mouse xenograft tumor model when dosed orally, Aurora inhibitor 1 exhibits good drug exposure levels across species upon oral dosing and shows excellent.

Chemical Properties

Molecular Weight	459.57
Formula	C₂₃H₂₅N₉S
Cas No.	2227019-45-4
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc