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N-Methylpyrrolidone

Name: N-Methylpyrrolidone
Brand: TargetMol
SKU: T5851
Rating: 4.5 (1 reviews)

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Catalog No. T5851Cas No. 872-50-4

Alias 1-Methyl-2-pyrrolidinone

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) is a five-membered cyclic amide and a widely used industrial organic polar solvent in the manufacture of adhesives, paints, fuels, and pharmaceuticals.

N-Methylpyrrolidone

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Purity: 98.28%

Catalog No. T5851Alias 1-Methyl-2-pyrrolidinoneCas No. 872-50-4

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) is a five-membered cyclic amide and a widely used industrial organic polar solvent in the manufacture of adhesives, paints, fuels, and pharmaceuticals.

Pack Size	Price	Availability
50 g	$43	Backorder
100 g	$59	Backorder
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:98.28%

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COA LCMS

Product Introduction

Bioactivity

Description	N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) is a five-membered cyclic amide and a widely used industrial organic polar solvent in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
In vivo	N-methylpyrrolidone produces skin irritation in humans and is teratogenic in rats. The molecular mechanisms underlying the biodegradation of N-methylpyrrolidone (NMP) are unknown.
Synonyms	1-Methyl-2-pyrrolidinone

Chemical Properties

Molecular Weight	99.13
Formula	C₅H₉NO
Cas No.	872-50-4
Smiles	O=C1N(C)CCC1
Relative Density.	1.03 g/cm3. Temperature:25 °C.

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (504.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	10.0878 mL	50.4388 mL	100.8776 mL	504.3882 mL
5 mM	2.0176 mL	10.0878 mL	20.1755 mL	100.8776 mL
10 mM	1.0088 mL	5.0439 mL	10.0878 mL	50.4388 mL
20 mM	0.5044 mL	2.5219 mL	5.0439 mL	25.2194 mL
50 mM	0.2018 mL	1.0088 mL	2.0176 mL	10.0878 mL
100 mM	0.1009 mL	0.5044 mL	1.0088 mL	5.0439 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc