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VDAC

Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30–40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.

  • VBIT-4
    T132872086257-77-2
    VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
    • $98
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  • Erastin
    T1765571203-78-6
    Erastin is an ferroptosis activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product is unstable in solution and is recommended to be dispensed now.
    • $41
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  • DIDS sodium salt
    T1897567483-13-0
    DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
    • $33
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  • VBIT-12
    T82152089227-65-4
    VBIT-12 is a potent inhibitor of VDAC1.
    • $76
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  • NSC 15364
    T35724550-72-5
    NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.
    • $54
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  • Tuvatexib
    T680182055404-90-3
    Tuvatexib is a small molecule VDAC/HK2 dual modulator.
    • $86
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