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ML-191

Name: ML-191
Brand: TargetMol
SKU: T22996
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22996Cas No. 931695-79-3

ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.

ML-191

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Purity: 99.58%

Catalog No. T22996Cas No. 931695-79-3

ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$329	In Stock	In Stock
200 mg	$465	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ML-191 AI Summary

ML-191 exhibits a broad spectrum of bioactivities. It acts as a selective antagonist of the GPR55 Receptor with an IC50 of 1080.0 nM and an agonist at the same receptor with an EC50 greater than 32000.0 nM. It also functions as an antagonist at the Cannabinoid Receptor 1 (IC50 = 17700.0 nM) and the GPR35 Receptor (IC50 > 32000.0 nM), while displaying agonist activity at the GPR35 Receptor with an EC50 greater than 32000.0 nM. Additionally, ML-191 shows potent inhibitory activity against Histone Lysine Methyltransferase G9a (IC50 = 125.9 nM) and displays inhibitory effects against the malarial parasite plastid (IC50 = 18526.0 nM). Notably, it serves as an inhibitor of TGF-beta (IC50 = 22387.2 nM) and the Hepatitis C Virus (HCV) (IC50 = 22387.2 nM), as well as a GLP-1 Receptor Inverse Agonist (IC50 = 28183.8 nM) and an inhibitor of Pin1 protein (IC50 = 100000.0 nM). ML-191 induces DNA re-replication in normal breast cells (IC50 = 20596.2 nM) and activates integrin-mediated alleviation for Muscular Dystrophy (IC50 = 3162.3 nM). It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the absence (IC50 = 12995.3 nM) and presence (IC50 = 25929.0 nM) of CPT, and serves as an antagonist of EPAC2 (IC50 = 39810.7 nM) and PTHR (IC50 = 8912.5 nM). The compound shows antiviral activity against Foot and Mouth Disease Virus (IC50 = 19952.6 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.

Chemical Properties

Molecular Weight	403.47
Formula	C₂₄H₂₅N₃O₃
Cas No.	931695-79-3
Smiles	Cc1ccc(cc1)C1(CC1)C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (136.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4785 mL	12.3925 mL	24.7850 mL	123.9250 mL
5 mM	0.4957 mL	2.4785 mL	4.9570 mL	24.7850 mL
10 mM	0.2478 mL	1.2392 mL	2.4785 mL	12.3925 mL
20 mM	0.1239 mL	0.6196 mL	1.2392 mL	6.1962 mL
50 mM	0.0496 mL	0.2478 mL	0.4957 mL	2.4785 mL
100 mM	0.0248 mL	0.1239 mL	0.2478 mL	1.2392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc