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3-Acetylcoumarin

Name: 3-Acetylcoumarin
Brand: TargetMol
SKU: Fr12596
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. Fr12596Cas No. 3949-36-8

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

3-Acetylcoumarin

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Purity: 99.31%

Catalog No. Fr12596Cas No. 3949-36-8

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.31%

Appearance:solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

3-Acetylcoumarin AI Summary

3-Acetylcoumarin demonstrates a variety of bioactivities across multiple biological systems. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells at a concentration of 200.0 µM, suggesting antioxidant properties. The compound exhibits DPPH radical scavenging activity of 0.83% at 25 µg/mL after 30 minutes and shows ABTS free radical inhibition by 63.58%. Moreover, it inhibits rat intestinal alpha-glucosidase by 53.19% at 100 µg/mL and displays inhibitory activity against Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 10,000.0 nM. Additionally, 3-Acetylcoumarin acts in a cytochrome panel assay with an AC50 of 199.53 nM and inhibits human recombinant MAO-B with an IC50 value of 14,450.0 nM, showing selectivity over MAO-A. In cancer research, it inhibits growth in various human tumor cell lines with GI50 values between 36,224.3 nM and 100,000.0 nM across different cancer types such as breast, melanoma, lung, prostate, colon, leukemia, central nervous system, ovarian, and renal cells. The compound also protects against pesticide-induced gastric lesions in Swiss albino mice, reducing lesions by 66.0% at a dose of 20 mg/kg orally. It shows moderate inhibitory activity against human CA9 with a Ki value of 151.8 nM and strong inhibitory activity against human CA12 with a Ki value of 7.8 nM. 3-Acetylcoumarin also inhibits the aggregation of HFIP-induced amyloid beta (1-42 residues), with inhibition rates between 40.0% to 59.0%, as measured by ThT fluorescence and turbidity assays. It demonstrates cytotoxicity against human SH-SY5Y cells with an IC50 of 75,000.0 nM and neuroprotective effects against amyloid beta-induced toxicity in the same cells with an activity level of 77.0%. Additionally, the compound shows antiviral activity against SARS-CoV-2 in VERO-6 cells, although with an IC50 value greater than 20,000.0 nM, it may not be highly potent in this assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

Chemical Properties

Molecular Weight	188.18
Formula	C₁₁H₈O₃
Cas No.	3949-36-8
Smiles	CC(=O)c1cc2ccccc2oc1=O
Relative Density.	1.285g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (132.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3141 mL	26.5703 mL	53.1406 mL	265.7031 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL	53.1406 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
20 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
50 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3141 mL
100 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc