Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

ATM/ATR

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. ATR is a serine/threonine kinase and belongs to the phosphoinositide 3- kinase related protein kinases (PIKKs), particularly to ATM (ataxia telangiectasia mutated) subfamily. It functions to maintain genome integrity by stabilizing replication forks and by regulating cell cycle progression and DNA repair.

  • Camonsertib
    T620832417489-10-0
    Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR (IC50: 120 nM) and is a more active inhibitor of ATM, DNA-PK and PI3Kα kinases. PK and PI3Kα kinases.
    • $172
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • Berzosertib
    T26691232416-25-9
    Berzosertib (VE-822) has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • Gartisertib
    T104071613191-99-3In house
    ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).
    • $1,200
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Ro 90-7501
    T16773293762-45-5In house
    Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.
    • $30
    In Stock
    Size
    QTY
  • AZ31
    T196712088113-98-6In house
    AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.
    • $45
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • KU60019
    T2474925701-49-1In house
    Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.
    • $48
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • AZ32
    T44432288709-96-4
    AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
    • $51
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Wortmannin
    T628319545-26-7
    Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • VE-821
    T30321232410-49-9
    VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki IC50: 13 26 nM in cell-free assays).
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Dactolisib
    T2235915019-65-7
    Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Torin 2
    T61001223001-51-1
    Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
    • $35
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • AZD0156
    T67701821428-35-6
    AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
    • $31
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • KU-55933
    T2685587871-26-9
    KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
    • $43
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Ceralasertib
    T33381352226-88-0
    Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
    • $43
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • NU6027
    T6612220036-08-8
    NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
    • $38
    In Stock
    Size
    QTY
  • ATR-IN-21
    T790312905312-17-4
    ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].
    • Inquiry Price
    Size
    QTY
  • ATR-IN-22
    T790332905312-07-2
    ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and demonstrates anti-tumor activity in colon cancer [1].
    • Inquiry Price
    Size
    QTY
  • AZ20
    T19581233339-22-4
    AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
    • $33
    In Stock
    Size
    QTY
  • ATM Inhibitor-8
    T79305
    ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of 1.15 nM.
    • Inquiry Price
    Size
    QTY
  • CP-466722
    T62611080622-86-1
    CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
    • $30
    In Stock
    Size
    QTY
  • A011
    T78711
    A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].
    • $143
    35 days
    Size
    QTY
  • ATR-IN-24
    T790582370889-43-1
    ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].
    • $1,520
    Backorder
    Size
    QTY
  • KU 59403
    T15673845932-30-1
    KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.
    • $882
    Backorder
    Size
    QTY
  • CGK733
    T1821905973-89-9
    CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.
    • $30
    In Stock
    Size
    QTY
  • Lartesertib
    T626842495096-26-7
    Lartesertib (ATM Inhibitor-5) is an inhibitor of serine/threonine protein kinase ATM with potential anticancer activity for the study of lung cancer.
    • $132
    In Stock
    Size
    QTY
  • GJ103 sodium salt
    T42511459687-96-7
    GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.
    • $42
    In Stock
    Size
    QTY
  • Garcinone C
    TN167376996-27-5
    Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effects on certain cancers.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • ATR-IN-29
    T791212761193-67-1
    ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
    • Inquiry Price
    Size
    QTY
  • ATM Inhibitor-9
    T79306
    ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].
    • Inquiry Price
    Size
    QTY
  • NU 7026
    T2433154447-35-5
    NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
    • $33
    In Stock
    Size
    QTY
  • Tuvusertib
    T104061613200-51-3
    Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
    • $68
    In Stock
    Size
    QTY
  • PIK-93
    T2616593960-11-3
    PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
    • $37
    In Stock
    Size
    QTY
  • (Z)-Mirin
    T31341198097-97-0
    (Z)-Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
    • $50
    In Stock
    Size
    QTY
  • KU-60019
    T63872925701-46-8
    KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).
    • $32
    In Stock
    Size
    QTY
  • M3541
    T708731360628-91-6
    M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage checkpoints, inhibits DNA damage repair, contributes to apoptosis, and induces death of ATM overexpressing tumor cells.
    • $518
    In Stock
    Size
    QTY
  • Elimusertib
    T73181876467-74-1
    Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.
    • $31
    In Stock
    Size
    QTY
  • ATR-IN-23
    T789592923800-62-6
    ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
    • $1,520
    Backorder
    Size
    QTY
  • Elimusertib hydrochloride(1876467-74-1 free base)
    T10468
    Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
    • $51
    In Stock
    Size
    QTY
  • ATM Inhibitor-1
    T103962135639-94-8
    ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM).
    • $2,420
    Backorder
    Size
    QTY
  • ETP-46464
    T20841345675-02-6
    ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
    • $34
    In Stock
    Size
    QTY
  • azd1390
    T51752089288-03-7
    AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.
    • $80
    In Stock
    Size
    QTY
  • Schisandrin B
    T292561281-37-6
    Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.
    • $35
    In Stock
    Size
    QTY