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Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody
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Catalog No. TMAB-10486
Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN2A (Ser140). Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody can be used in FCM.
Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody
Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody
😃Good
Catalog No. TMAB-10486
Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN2A (Ser140). Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN2A (Ser140). Anti-Phospho-CDKN2A (Ser140) Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 3μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human CDKN2A around the phosphorylation site of Ser140 |
| Antigen Species | Human |
| Gene Name | Cdkn2a |
| Gene ID | |
| Protein Name | Tumor suppressor ARF |
| Uniprot ID | |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Molecular Weight | Theoretical: 17 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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