Carboxylesterase 2/CES2 Protein, Human, Recombinant (GST)

Catalog No. TMPC-00148 Copy Product Info

Carboxylesterase 2/CES2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O00748.

Carboxylesterase 2/CES2 Protein, Human, Recombinant (GST)

Catalog No. TMPC-00148

Copy Product Info

Carboxylesterase 2/CES2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O00748.

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10 μg	$1,430	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of CES2 was determined to be 7,051 pmol/min/μg by a carboxylesterase assay.
Description	Carboxylesterase 2/CES2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O00748.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	O00748
Synonyms	ICE,hCE-2,Cocaine esterase,CES2,CE-2,Carboxylesterase 2
Construction	Recombinant full length human CES2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>80% as determined by SDS-PAGE.
Molecular Weight	~90 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.