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Anti-Serpin A1 Antibody (6H814)
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Catalog No. TMAY-00590
Alias α1AT, SerpinA1, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, PRO2275, PI1, PI, MGC9222, MGC23330, alpha1AT, AAT, A1AT, A1A
Anti-Serpin A1 Antibody (6H814) is a Rabbit antibody targeting Serpin A1. Anti-Serpin A1 Antibody (6H814) can be used in ELISA.
Anti-Serpin A1 Antibody (6H814)
Anti-Serpin A1 Antibody (6H814)
😃Good
Catalog No. TMAY-00590Alias α1AT, SerpinA1, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, PRO2275, PI1, PI, MGC9222, MGC23330, alpha1AT, AAT, A1AT, A1A
Anti-Serpin A1 Antibody (6H814) is a Rabbit antibody targeting Serpin A1. Anti-Serpin A1 Antibody (6H814) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-Serpin A1 Antibody (6H814) is a Rabbit antibody targeting Serpin A1. Anti-Serpin A1 Antibody (6H814) can be used in ELISA. |
| Alias | α1AT, SerpinA1, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, PRO2275, PI1, PI, MGC9222, MGC23330, alpha1AT, AAT, A1AT, A1A |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 6H814 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA1 (rh SerpinA1; TMPY-00915; NP_000286.3; Met 1-Lys 418). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human SerpinA1 protein (TMPY-00915) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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