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IL-37 Protein, Human, Recombinant
(Synonyms: interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1) Copy Product InfoSynonyms: interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1
Catalog No. TMPY-02597 Copy Product Info
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $80 | 7-10 days | 7-10 days | |
| 10 μg | $129 | 7-10 days | 7-10 days | |
| 20 μg | $212 | - | In Stock | |
| 50 μg | $388 | 7-10 days | 7-10 days | |
| 100 μg | $618 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:≥ 96 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Appearance:Lyophilized powder
Color:White
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| Description | Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy. |
| Species | Human |
| Expression System | E. coli |
| Tag | Tag Free |
| Accession Number | Q9NZH6-2 |
| Construction | A DNA sequence encoding the mature form of human IL1F7 isoform A (Q9NZH6-2) (Lys 27-Asp 192) was expressed and purified, with an initial Met. Predicted N terminal: Met |
| Protein Purity | > 96 % as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1 |
| Research Background |
| Molecular Weight | 18.7 kDa (predicted) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: IL-37 Protein, Human, Recombinant chemical structure | IL-37 Protein, Human, Recombinant molecular weight
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