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Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody
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Catalog No. TMAB-10908
Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIMK1/LIMK2 (Thr508/Thr505). Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody
Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody
😃Good
Catalog No. TMAB-10908
Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIMK1/LIMK2 (Thr508/Thr505). Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIMK1/LIMK2 (Thr508/Thr505). Anti-Phospho-LIMK1/LIMK2 (Thr508/Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. |
| Tissue Specificity | Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human LIMK1 around the phosphorylation site of Thr508 |
| Antigen Species | Human |
| Gene Name | LIMK1 |
| Gene ID | |
| Protein Name | LIM domain kinase 2 |
| Uniprot ID | |
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. |
| Molecular Weight | Theoretical: 71 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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