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Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody

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Catalog No. TMAB-01457
Alias YSK3, TIIAC, STK4, STK 4, STE20-like kinase MST1, STE20 like kinase MST1, Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 18kDa subunit, Serine/threonine-protein kinase 4, Serine/threonine protein kinase Krs 2, Serine/threonine kinase 4, p-MST1 /2 (Thr183, 180), p-MST1 /2 (T183, 180), MST1/N, MST1/C, MST1 /2 (p-Thr183, 180), MST1 /2 (p-T183, 180), MST-1, Mammalian sterile 20 like 1, Mammalian STE20 like protein kinase 1, Krs2, Kinase responsive to stress

Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MST1 /2 (Thr183, 180). Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody can be used in WB.

Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody

Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody

😃Good
Catalog No. TMAB-01457Alias YSK3, TIIAC, STK4, STK 4, STE20-like kinase MST1, STE20 like kinase MST1, Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 18kDa subunit, Serine/threonine-protein kinase 4, Serine/threonine protein kinase Krs 2, Serine/threonine kinase 4, p-MST1 /2 (Thr183, 180), p-MST1 /2 (T183, 180), MST1/N, MST1/C, MST1 /2 (p-Thr183, 180), MST1 /2 (p-T183, 180), MST-1, Mammalian sterile 20 like 1, Mammalian STE20 like protein kinase 1, Krs2, Kinase responsive to stress
Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MST1 /2 (Thr183, 180). Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3747-10 days
200 μL$5297-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MST1 /2 (Thr183, 180). Anti-Phospho-MST1 /2 (Thr183, 180) Polyclonal Antibody can be used in WB.
SynonymsYSK3, TIIAC, STK4, STK 4, STE20-like kinase MST1, STE20 like kinase MST1, Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 18kDa subunit, Serine/threonine-protein kinase 4, Serine/threonine protein kinase Krs 2, Serine/threonine kinase 4, p-MST1 /2 (Thr183, 180), p-MST1 /2 (T183, 180), MST1/N, MST1/C, MST1 /2 (p-Thr183, 180), MST1 /2 (p-T183, 180), MST-1, Mammalian sterile 20 like 1, Mammalian STE20 like protein kinase 1, Krs2, Kinase responsive to stress
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit)
Verified Activity
1. Sample:
Hela (Human) Cell Lysate at 30 μg
Primary: Anti-Phospho-Mst1 (Thr183) + Mst2 (Thr180) (TMAB-01457) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 19/37/56 kDa
Observed band size: 37 kDa
2. Sample:
HepG2 (Human) Cell Lysate at 30 μg
Primary: Anti-Phospho-Mst1 (Thr183) + Mst2 (Thr180) (TMAB-01457) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 19/37/56 kDa
Observed band size: 37 kDa
3. Sample:
293t (Human) Cell Lysate at 30 μg
Primary: Anti-Phospho-Mst1 (Thr183) + Mst2 (Thr180) (TMAB-01457) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 19/37/56 kDa
Observed band size: 37 kDa
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Tissue SpecificityExpressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human Mst1 around the phosphorylation site of Thr183
Antigen Species
Human
Gene Name
STK4
Gene ID
Protein Name
Serine/threonine-protein kinase 4
Uniprot ID
Biology Area
Apoptosis,Hypertrophy,Other Kinases
Function
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Chemical Properties
Molecular WeightTheoretical: 19/37/56 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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