OTS186935 trihydrochloride

Name: OTS186935 trihydrochloride
Brand: TargetMol
SKU: T12344L
Rating: 4.5 (1 reviews)

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Catalog No. T12344LCas No. 2093401-85-3

OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.

OTS186935 trihydrochloride

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Catalog No. T12344LCas No. 2093401-85-3

OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	1-2 weeks	1-2 weeks
50 mg	$1,980	1-2 weeks	1-2 weeks
100 mg	$2,500	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.
Targets&IC50	SUV39H2:6.49 nM
In vitro	OTS186935 trihydrochloride, revealed significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity.??SUV39H2 inhibitors sensitize cancer cells to DOX by reduction of γ-H2AX levels in cancer cells
In vivo	OTS186935 trihydrochloride?exhibits growth suppressive effects in human cancer cell line derived xenograft models[1].

Chemical Properties

Molecular Weight	573.34
Formula	C₂₅H₂₉Cl₄N₅O₂
Cas No.	2093401-85-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc