OTS186935 trihydrochloride

Name: OTS186935 trihydrochloride
Brand: TargetMol
SKU: T12344L
Rating: 4.5 (1 reviews)

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Catalog No. T12344LCas No. 2093401-85-3

OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.

OTS186935 trihydrochloride

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Catalog No. T12344LCas No. 2093401-85-3

OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	1-2 weeks	1-2 weeks
50 mg	$1,980	1-2 weeks	1-2 weeks
100 mg	$2,500	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	OTS186935 trihydrochloride, a protein methyltransferase inhibitor of SUV39H2, has an IC50 of 6.49 nM.
Targets&IC50	SUV39H2:6.49 nM
In vitro	OTS186935 trihydrochloride, revealed significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity.??SUV39H2 inhibitors sensitize cancer cells to DOX by reduction of γ-H2AX levels in cancer cells
In vivo	OTS186935 trihydrochloride?exhibits growth suppressive effects in human cancer cell line derived xenograft models[1].

Chemical Properties

Molecular Weight	573.34
Formula	C₂₅H₂₉Cl₄N₅O₂
Cas No.	2093401-85-3
Smiles	Cl.Cl.Cl.COc1cc(OC)c(cc1Cl)-c1cn2ccc(cc2n1)N1CC[C@@H](C1)NCc1ccncc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc