Shopping Cart
Remove All
Your shopping cart is currently empty
DPO-1
Catalog No. T22745 Copy Product Info
Purity: 99.78%
😃Good
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
DPO-1
Copy Product Info😃Good
Catalog No. T22745
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
Cas No. 43077-30-1
Customer service consultation
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | $41 | In Stock | In Stock | |
| 10 mg | $68 | In Stock | In Stock | |
| 25 mg | $153 | In Stock | In Stock | |
| 50 mg | $228 | In Stock | In Stock | |
| 100 mg | $329 | In Stock | In Stock | |
| 200 mg | $461 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:99.78%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
DPO-1 AI Summary
DPO-1 is a potent inhibitor of the human Kv1.5 ion channel, demonstrating an IC50 of 30.0 nM in CHO cells and 500.0 nM within 3 minutes in a high-throughput planar patch clamp assay. It has a high lipophilicity with a log D value of 6.0 at pH 7.4 and exhibits significant plasma protein binding at 99.61%. The compound shows diverse bioactivities across various assays, including mitochondrial division inhibition (IC50 = 2592.9 nM), inhibition of histone lysine methyltransferase G9a (IC50 = 8912.5 nM), potent inhibition of HP1-beta chromodomain interactions (IC50 = 4.7 nM), and moderate inhibition of human FEN1 (IC50 = 8436.8 nM).
Additionally, it enhances Arylsulfatase A activity with a potency of 268.5 nM. DPO-1 exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (2.22% inhibition at 10 µM after 48 hours) and VERO-6 cells (0.24% inhibition at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2). It also inhibits SARS-CoV-2 3CL-Pro protease activity by 6.408% at 20 µM.
Regarding enzyme activity, DPO-1 shows variable inhibition of human HDAC6, with a decrease of 9.96% using a commercial peptide substrate and an increase of 14.03% using a custom substrate. Its effect on cell viability varies between cell types, exhibiting lower growth rates in HEK293T and human fibroblast cells but higher rates in U2OS cells according to Incucyte cell viability assays. This suggests potential cell-type-specific bioactivities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels |
| Molecular Weight | 340.44 |
| Formula | C22H29OP |
| Cas No. | 43077-30-1 |
| Smiles | P(=O)([C@@H]1[C@H](C(C)C)CC[C@@H](C)C1)(C2=CC=CC=C2)C3=CC=CC=C3 |
| Relative Density. | 1.054g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.41 mg/mL (10.02 mM), Sonication is recommended.  Ethanol: < 34.04 mg/mL, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy DPO-1 | purchase DPO-1 | DPO-1 cost | order DPO-1 | DPO-1 chemical structure | DPO-1 formula | DPO-1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.