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DPO-1
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Catalog No. T22745Cas No. 43077-30-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
DPO-1
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Purity: 99.78%
Catalog No. T22745Cas No. 43077-30-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $41 | In Stock | In Stock | |
| 10 mg | $68 | In Stock | In Stock | |
| 25 mg | $153 | In Stock | In Stock | |
| 50 mg | $228 | In Stock | In Stock | |
| 100 mg | $329 | In Stock | In Stock | |
| 200 mg | $461 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.78%
Appearance:Solid
Color:White
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Product Introduction
DPO-1 AI Summary
DPO-1 is a potent inhibitor of the human Kv1.5 ion channel, demonstrating an IC50 of 30.0 nM in CHO cells and 500.0 nM within 3 minutes in a high-throughput planar patch clamp assay. It has a high lipophilicity with a log D value of 6.0 at pH 7.4 and exhibits significant plasma protein binding at 99.61%. The compound shows diverse bioactivities across various assays, including mitochondrial division inhibition (IC50 = 2592.9 nM), inhibition of histone lysine methyltransferase G9a (IC50 = 8912.5 nM), potent inhibition of HP1-beta chromodomain interactions (IC50 = 4.7 nM), and moderate inhibition of human FEN1 (IC50 = 8436.8 nM).
Additionally, it enhances Arylsulfatase A activity with a potency of 268.5 nM. DPO-1 exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (2.22% inhibition at 10 µM after 48 hours) and VERO-6 cells (0.24% inhibition at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2). It also inhibits SARS-CoV-2 3CL-Pro protease activity by 6.408% at 20 µM.
Regarding enzyme activity, DPO-1 shows variable inhibition of human HDAC6, with a decrease of 9.96% using a commercial peptide substrate and an increase of 14.03% using a custom substrate. Its effect on cell viability varies between cell types, exhibiting lower growth rates in HEK293T and human fibroblast cells but higher rates in U2OS cells according to Incucyte cell viability assays. This suggests potential cell-type-specific bioactivities..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels |
| Molecular Weight | 340.44 |
| Formula | C22H29OP |
| Cas No. | 43077-30-1 |
| Smiles | P(=O)([C@@H]1[C@H](C(C)C)CC[C@@H](C)C1)(C2=CC=CC=C2)C3=CC=CC=C3 |
| Relative Density. | 1.054g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.41 mg/mL (10.02 mM), Sonication is recommended.  Ethanol: < 34.04 mg/mL, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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