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Anti-BCL10 Antibody (7U625)

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Catalog No. TMAB-03045

Anti-BCL10 Antibody (7U625) is a Mouse antibody targeting BCL10. Anti-BCL10 Antibody (7U625) can be used in WB,IHC-P,IHC-Fr,IF,FCM.

Anti-BCL10 Antibody (7U625)

Anti-BCL10 Antibody (7U625)

😃Good
Catalog No. TMAB-03045
Anti-BCL10 Antibody (7U625) is a Mouse antibody targeting BCL10. Anti-BCL10 Antibody (7U625) can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-BCL10 Antibody (7U625) is a Mouse antibody targeting BCL10. Anti-BCL10 Antibody (7U625) can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG1, k
Clone
7U625
Reactivity
Human,Mouse
Application
WB
IHC-P
IHC-Fr
IF
FCM
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Tissue SpecificityUbiquitous.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human BCL10
Antigen Species
Human
Gene Name
BCL10
Gene ID
8915
Protein Name
B-cell lymphoma/leukemia 10
Uniprot ID
O95999
Function
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Chemical Properties
Molecular WeightTheoretical: 26 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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