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MS44
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Catalog No. T212241
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.
MS44
MS44
😃Good
Catalog No. T212241
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors. |
| Targets&IC50 | Aurora B:103 nM (DC50) |
| In vitro | MS44 (Compound 18) effectively degrades AURKB in HPAF-11 cells by hijacking the UPS, demonstrating a concentration and time-dependent action (1 nM-10 μM, 1-96 h), and exhibits similar effects across various cancer cell lines. It inhibits the proliferation of HPAF-11, K562, U937, CFPAC-1, SW1783, and HT-29 cells at 1 μM over 24-96 hours. Additionally, MS44 induces G2/M phase arrest in U937 cells within 48 hours. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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