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NT1-O14B

Name: NT1-O14B
Brand: TargetMol
SKU: T84737
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T84737Cas No. 2739805-64-0

Alias NT1O14B, NT1-014B

NT1-O14B is a novel class of neurotransmitter tryptophan lipids (NT-lipidoids).NT1-O14B can be combined with small molecule drugs (e.g., AmB) and biomolecules (e.g., Tau-ASO) and gene editing proteins (GFP-Cre) to form new neurotransmitter-derived lipid nanoparticles (NT-LNPs) that have blood-brain-barrier (BBB) permeability. Enhanced lipid hydrophobicity and membrane fusion capabilities are commonly used for delivery of nucleic acids such as mRNA, siRNA and DNA.

NT1-O14B

🥰Excellent

Purity: 98.75%

Catalog No. T84737Alias NT1O14B, NT1-014BCas No. 2739805-64-0

Pack Size	Price	Availability
5 mg	$42	In Stock
10 mg	$59	In Stock
25 mg	Preferential	In Stock
50 mg	Preferential	In Stock

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Batch Information

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Purity:98.75%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Synonyms

NT1O14B, NT1-014B

Chemical Properties

Molecular Weight	769.24
Formula	C₄₀H₆₈N₂O₄S₄
Cas No.	2739805-64-0
Smiles	CCCCCCCCCCSSCCOC(=O)CCN(CCC(=O)OCCSSCCCCCCCCCC)CCc1c[nH]c2ccccc12
Color	Transparent
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (156 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3000 mL	6.4999 mL	12.9998 mL	64.9992 mL
5 mM	0.2600 mL	1.3000 mL	2.6000 mL	12.9998 mL
10 mM	0.1300 mL	0.6500 mL	1.3000 mL	6.4999 mL
20 mM	0.0650 mL	0.3250 mL	0.6500 mL	3.2500 mL
50 mM	0.0260 mL	0.1300 mL	0.2600 mL	1.3000 mL
100 mM	0.0130 mL	0.0650 mL	0.1300 mL	0.6500 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc