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NT1-O14B

Name: NT1-O14B
Brand: TargetMol
SKU: T84737
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T84737Cas No. 2739805-64-0

Alias NT1O14B, NT1-014B

NT1-O14B is a novel class of neurotransmitter tryptophan lipids (NT-lipidoids).NT1-O14B can be combined with small molecule drugs (e.g., AmB) and biomolecules (e.g., Tau-ASO) and gene editing proteins (GFP-Cre) to form new neurotransmitter-derived lipid nanoparticles (NT-LNPs) that have blood-brain-barrier (BBB) permeability. Enhanced lipid hydrophobicity and membrane fusion capabilities are commonly used for delivery of nucleic acids such as mRNA, siRNA and DNA.

NT1-O14B

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Purity: 98.75%

Catalog No. T84737Alias NT1O14B, NT1-014BCas No. 2739805-64-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	-	In Stock
10 mg	$59	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.75%

Appearance:Oil

Color:Transparent

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Synonyms

NT1O14B, NT1-014B

Chemical Properties

Molecular Weight	769.24
Formula	C₄₀H₆₈N₂O₄S₄
Cas No.	2739805-64-0
Smiles	CCCCCCCCCCSSCCOC(=O)CCN(CCC(=O)OCCSSCCCCCCCCCC)CCc1c[nH]c2ccccc12

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (156 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3000 mL	6.4999 mL	12.9998 mL	64.9992 mL
5 mM	0.2600 mL	1.3000 mL	2.6000 mL	12.9998 mL
10 mM	0.1300 mL	0.6500 mL	1.3000 mL	6.4999 mL
20 mM	0.0650 mL	0.3250 mL	0.6500 mL	3.2500 mL
50 mM	0.0260 mL	0.1300 mL	0.2600 mL	1.3000 mL
100 mM	0.0130 mL	0.0650 mL	0.1300 mL	0.6500 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc