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Aldoxorubicin

Name: Aldoxorubicin
Brand: TargetMol
SKU: T11090L
Rating: 4.5 (1 reviews)

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Catalog No. T11090LCas No. 1361644-26-9

Alias INNO-206, DOXO-EMCH

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

Aldoxorubicin

😃Good

Catalog No. T11090LAlias INNO-206, DOXO-EMCHCas No. 1361644-26-9

Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
In vitro	Aldoxorubicin (0.27 to 2.16 μM) suppresses blood vessel formation. Aldoxorubicin (0.27 to 2.16 μM) also reduces multiple myeloma cell growth in a pH-dependent fashion.
In vivo	Aldoxorubicin displays a good safety profile at doses up to 260 mg/mL doxorubicin equivalents and is able to cause tumor regressions in breast cancer, small cell lung cancer, and sarcoma in phase I study[2]. In a murine renal cell carcinoma model and in breast carcinoma xenograft models, Aldoxorubicin also shows superior activity over doxorubicin [3]. On days 28, Aldoxorubicin (10.8 mg/kg, i.v.) displays obviously smaller tumor volumes and IgG levels, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1].
Synonyms	INNO-206, DOXO-EMCH

Chemical Properties

Molecular Weight	750.75
Formula	C₃₇H₄₂N₄O₁₃
Cas No.	1361644-26-9
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](\C(=N\NC(CCCCCN4C(=O)C=CC4=O)=O)\CO)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (99.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3320 mL	6.6600 mL	13.3200 mL	66.6001 mL
5 mM	0.2664 mL	1.3320 mL	2.6640 mL	13.3200 mL
10 mM	0.1332 mL	0.6660 mL	1.3320 mL	6.6600 mL
20 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3300 mL
50 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3320 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc