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B-Raf IN 11

Name: B-Raf IN 11
Brand: TargetMol
SKU: T19802
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19802Cas No. 918504-27-5

B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.

B-Raf IN 11

🥰Excellent

Purity: 99.947%

Catalog No. T19802Cas No. 918504-27-5

B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.

Pack Size	Price	Availability	Quantity
50 mg	$30	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.947%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.
Targets&IC50	B-Raf (WT):238 nM, B-Raf (V600E):76 nM

Chemical Properties

Molecular Weight	458.28
Formula	C₁₇H₁₄BrF₂N₃O₃S
Cas No.	918504-27-5
Smiles	C(=O)(C=1C=2C(NC1)=NC=C(Br)C2)C3=C(F)C(NS(CCC)(=O)=O)=CC=C3F
Relative Density.	1.689 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (130.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1821 mL	10.9104 mL	21.8207 mL	109.1036 mL
5 mM	0.4364 mL	2.1821 mL	4.3641 mL	21.8207 mL
10 mM	0.2182 mL	1.0910 mL	2.1821 mL	10.9104 mL
20 mM	0.1091 mL	0.5455 mL	1.0910 mL	5.4552 mL
50 mM	0.0436 mL	0.2182 mL	0.4364 mL	2.1821 mL
100 mM	0.0218 mL	0.1091 mL	0.2182 mL	1.0910 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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