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B7-2/CD86 Protein, Human, Recombinant (hFc)
(Synonyms: MGC34413, LAB72, FUN-1, CD86 molecule, CD86, CD28LG2, BU63, B7-2 antigen, B7-2, B72, B70) Copy Product InfoSynonyms: MGC34413, LAB72, FUN-1, CD86 molecule, CD86, CD28LG2, BU63, B7-2 antigen, B7-2, B72, B70
Catalog No. TMPK-00882 Copy Product Info
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 52 kDa and the accession number is P42081-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $39 | 7-10 days | 7-10 days | |
| 10 μg | $60 | 7-10 days | 7-10 days | |
| 20 μg | $95 | 7-10 days | 7-10 days | |
| 50 μg | $182 | 7-10 days | 7-10 days | |
| 100 μg | $302 | 7-10 days | 7-10 days | |
| 200 μg | $547 | 7-10 days | 7-10 days | |
| 500 μg | $1,210 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human CTLA-4, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human B7-2, hFc Tag with the EC50 of 125.7ng/ml determined by ELISA. |
| Description | B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 52 kDa and the accession number is P42081-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P42081-1 |
| Construction | Leu26-Pro247 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | MGC34413, LAB72, FUN-1, CD86 molecule, CD86, CD28LG2, BU63, B7-2 antigen, B7-2, B72, B70 |
| Research Background |
| Molecular Weight | 52 kDa (predicted). Due to glycosylation, the protein migrates to 75-90 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: B7-2/CD86 Protein, Human, Recombinant (hFc) chemical structure | B7-2/CD86 Protein, Human, Recombinant (hFc) molecular weight
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