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Anti-Cystatin B Antibody (3X196)

😃Good
Catalog No. TMAY-00828
Alias ULD, STFB, PME, EPM1A, EPM1, cystatin B (stefin B), CST6

Anti-Cystatin B Antibody (3X196) is a Mouse antibody targeting Cystatin B. Anti-Cystatin B Antibody (3X196) can be used in ELISA(Cap).

Anti-Cystatin B Antibody (3X196)

Anti-Cystatin B Antibody (3X196)

😃Good
Catalog No. TMAY-00828Alias ULD, STFB, PME, EPM1A, EPM1, cystatin B (stefin B), CST6
Anti-Cystatin B Antibody (3X196) is a Mouse antibody targeting Cystatin B. Anti-Cystatin B Antibody (3X196) can be used in ELISA(Cap).
Pack SizePriceAvailabilityQuantity
20 μL$68 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Cystatin B Antibody (3X196) is a Mouse antibody targeting Cystatin B. Anti-Cystatin B Antibody (3X196) can be used in ELISA(Cap).
AliasULD, STFB, PME, EPM1A, EPM1, cystatin B (stefin B), CST6
Ig Type
Monoclonal Mouse IgG1
Clone
3X196
Reactivity
Human
Application
ELISA(Cap)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin B (rh Cystatin B; TMPY-02090; P04080; Met2-Phe98). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0
Research BackgroundCystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to thecystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. Cystatins typically comprise about 115 amino acids, are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds. Cystatins may be glycosylated and / or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired inhibitory activity. Cystatins mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family).
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Cystatin B Protein (TMPY-02090)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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