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G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $128 | In Stock | |
5 mg | $275 | In Stock | |
10 mg | $432 | In Stock | |
25 mg | $715 | In Stock | |
50 mg | $1,000 | In Stock | |
100 mg | $1,350 | In Stock | |
200 mg | $1,830 | In Stock | |
1 mL x 10 mM (in DMSO) | $301 | In Stock |
Description | G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS). |
Targets&IC50 | cGAS (human):10.2 nM |
In vitro | G150 showed dose-dependent inhibitory activity in THP1 cells with cellular IC50 of 1.96 μM[1]. |
Molecular Weight | 391.25 |
Formula | C18H16Cl2N4O2 |
Cas No. | 2369751-30-2 |
Smiles | Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO |
Relative Density. | 1.545 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (306.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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