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G150

Name: G150
Brand: TargetMol
SKU: T11344
Price: 128 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11344Cas No. 2369751-30-2

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).

G150

🥰Excellent

Purity: 97.75%

Catalog No. T11344Cas No. 2369751-30-2

G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).

Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$275	In Stock
10 mg	$425	In Stock
25 mg	$713	In Stock
50 mg	$929	In Stock
100 mg	$1,190	In Stock
200 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$301	In Stock

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Purity:97.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).
Targets&IC50	cGAS (human):10.2 nM
In vitro	G150 showed dose-dependent inhibitory activity in THP1 cells with cellular IC50 of 1.96 μM[1].

Chemical Properties

Molecular Weight	391.25
Formula	C₁₈H₁₆Cl₂N₄O₂
Cas No.	2369751-30-2
Smiles	Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO
Relative Density.	1.545 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (306.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5559 mL	12.7796 mL	25.5591 mL	127.7955 mL
5 mM	0.5112 mL	2.5559 mL	5.1118 mL	25.5591 mL
10 mM	0.2556 mL	1.2780 mL	2.5559 mL	12.7796 mL
20 mM	0.1278 mL	0.6390 mL	1.2780 mL	6.3898 mL
50 mM	0.0511 mL	0.2556 mL	0.5112 mL	2.5559 mL
100 mM	0.0256 mL	0.1278 mL	0.2556 mL	1.2780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc