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Norepinephrine is an alkaloid neurotransmitter and an effective adrenergic receptor (AR) agonist that activates α1, α2, and β1 receptors. It is commonly used as a vasoactive agent for the treatment of shock and can also be used to induce cardiomyopathy models.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $31 | In Stock | |
100 mg | $41 | In Stock | |
500 mg | $89 | In Stock | |
1 g | $129 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Norepinephrine is an alkaloid neurotransmitter and an effective adrenergic receptor (AR) agonist that activates α1, α2, and β1 receptors. It is commonly used as a vasoactive agent for the treatment of shock and can also be used to induce cardiomyopathy models. |
Targets&IC50 | α2A-adrenoceptor:56 nM (Ki), β1-adrenoceptor:740 nM (Ki), α1-adrenoceptor:330 nM (Ki) |
In vitro | METHODS: Adult hippocampal cells were treated with Norepinephrine (0.1-10 µM) for 10-13 days and the number of neurospheres was determined using classical neurosphere assay. RESULTS: A significant increase in the number of neurospheres was obtained at 100 nm and in the presence of 1 µM Norepinephrine, and a twofold increase in the number of neurospheres was observed in the presence of 10 µM Norepinephrine. [1] METHODS: Human pancreatic cancer cells BxPC-3 and Panc-1 were treated with Norepinephrine (10 µM) for 12-48 h. Cell viability was assayed by MTT Assay. RESULTS: Norepinephrine treatment alone significantly enhanced the viability of PDAC cells. [2] |
In vivo | METHODS: To test in vivo activity, Norepinephrine (0.2-2 mg/kga) was administered intraperitoneally to C57BL6/J mice fed a high-fat diet once daily for two weeks. RESULTS: A subset of Norepinephrine-treated mice developed unexpected adverse events, including bladder dilatation and decreased renal perfusion due to renal discoloration. [3] |
Synonyms | Nor-Epirenan, L-Noradrenaline, Levophed, Levonoradrenaline, Levonor, Arterenol, Aktamin |
Molecular Weight | 169.18 |
Formula | C8H11NO3 |
Cas No. | 51-41-2 |
Smiles | [C@@H](CN)(O)C1=CC(O)=C(O)C=C1 |
Relative Density. | 1.397 g/cm3 |
Storage | keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
Solubility Information | 0.1M HCl: 10 mg/mL (59.11 mM), Sonication is recommended. ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) ![]() DMSO: 8.46 mg/mL (50.01 mM), Sonication and heating are recommended. ![]() | ||||||||||||||||||||||||||||||
In Vivo Formulation | 10% DMSO+90% Saline: 0.1 mg/mL (0.59 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/0.1M HCl
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