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3,4-Dibromo-Mal-PEG2-N-Boc

Name: 3,4-Dibromo-Mal-PEG2-N-Boc
Brand: TargetMol
SKU: T14025
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14025Cas No. 1807537-43-4

3,4-Dibromo-Mal-PEG2-N-Boc is a PEGylated PROTAC linker that enables conjugation between target-binding ligands and E3 ligase ligands during PROTAC assembly. 3,4-Dibromo-Mal-PEG2-N-Boc supports the design of heterobifunctional degraders that exploit the ubiquitin–proteasome system for selective protein degradation。

3,4-Dibromo-Mal-PEG2-N-Boc

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Purity: 99.24%

Catalog No. T14025Cas No. 1807537-43-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	-	In Stock
25 mg	$45	-	In Stock
50 mg	$66	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.24%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	3,4-Dibromo-Mal-PEG2-N-Boc is a PEGylated PROTAC linker that enables conjugation between target-binding ligands and E3 ligase ligands during PROTAC assembly. 3,4-Dibromo-Mal-PEG2-N-Boc supports the design of heterobifunctional degraders that exploit the ubiquitin–proteasome system for selective protein degradation。
In vitro	PROTACs are compounds that consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade the target proteins[1].

Chemical Properties

Molecular Weight	486.15
Formula	C₁₅H₂₂Br₂N₂O₆
Cas No.	1807537-43-4
Smiles	O=C(OC(C)(C)C)NCCOCCOCCN1C(=O)C(Br)=C(Br)C1=O
Relative Density.	1.609 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (164.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0570 mL	10.2849 mL	20.5698 mL	102.8489 mL
5 mM	0.4114 mL	2.0570 mL	4.1140 mL	20.5698 mL
10 mM	0.2057 mL	1.0285 mL	2.0570 mL	10.2849 mL
20 mM	0.1028 mL	0.5142 mL	1.0285 mL	5.1424 mL
50 mM	0.0411 mL	0.2057 mL	0.4114 mL	2.0570 mL
100 mM	0.0206 mL	0.1028 mL	0.2057 mL	1.0285 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc