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Anti-Podoplanin Antibody (6Y710)
😃Good
Catalog No. TMAH-00873
Alias TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS
Anti-Podoplanin Antibody (6Y710) is an antibody targeting Podoplanin. Anti-Podoplanin Antibody (6Y710) can be used in ELISA.
Anti-Podoplanin Antibody (6Y710)
Anti-Podoplanin Antibody (6Y710)
😃Good
Catalog No. TMAH-00873Alias TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS
Anti-Podoplanin Antibody (6Y710) is an antibody targeting Podoplanin. Anti-Podoplanin Antibody (6Y710) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA Reactivity: Human |
| Alias | TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS |
| Ig Type | Rabbit IgG |
| Clone | 6Y710 |
| Reactivity | Human |
| Application | ELISA |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Podoplanin]: Membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium.; [29kDa cytosolic podoplanin intracellular domain]: Cytoplasm, cytosol. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells. In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation. Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1. Required for normal lung cell proliferation and alveolus formation at birth. Does not function as a water channel or as a regulator of aquaporin-type water channels. Does not have any effect on folic acid or amino acid transport. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PDPN |
| Antigen Species | Human |
| Gene ID | 10630 |
| Uniprot ID | |
| Biology Area | Cardiovascular |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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