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Kobe2602

Name: Kobe2602
Brand: TargetMol
SKU: T1892
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1892Cas No. 454453-49-7

Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.

Kobe2602

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Purity: 99.39%

Catalog No. T1892Cas No. 454453-49-7

Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$73	In Stock	In Stock
100 mg	$118	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:Solid

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
Targets&IC50	Ras:149 μM(Ki)
Kinase Assay	Migration assays: Assays are conducted in wells of a 24-well, 8 μm pore size Transwell plate. A 6.5-mm insert membrane is coated with 0.1 mL COL-I (300 μg/mL in MEGM) and then air dried for 16 hours. The collagen coating is rehydrated for 1 hour in 0.2 mL MEGM. The inner chamber contains MEGM-10% FBS as a chemoattractant. The compounds (10–100 μmol/L) or DMSO (0.1%–1%) are added to both inner and outer chambers. Before plating in the outer chamber, cells (5×104) are coincubated for 20 minutes with the compounds or DMSO in MEGM. Cells are allowed to migrate for 16 to 18 hours. The cells remaining on the top surface of the membrane are removed with a cotton swab. The cells on the bottom surface of the membrane are fixed and stained (0.2% crystal violet). The incorporated dye is extracted with 1% SDS and the A570 is measured.

Chemical Properties

Molecular Weight	419.31
Formula	C₁₄H₉F₄N₅O₄S
Cas No.	454453-49-7
Smiles	[O-][N+](=O)c1cc(cc(c1NNC(=S)Nc1ccc(F)cc1)[N+]([O-])=O)C(F)(F)F
Relative Density.	1.691 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3849 mL	11.9244 mL	23.8487 mL	119.2435 mL
5 mM	0.4770 mL	2.3849 mL	4.7697 mL	23.8487 mL
10 mM	0.2385 mL	1.1924 mL	2.3849 mL	11.9244 mL
20 mM	0.1192 mL	0.5962 mL	1.1924 mL	5.9622 mL
50 mM	0.0477 mL	0.2385 mL	0.4770 mL	2.3849 mL
100 mM	0.0238 mL	0.1192 mL	0.2385 mL	1.1924 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc