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Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody
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Catalog No. TMAB-11188
Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PSD93 (Tyr340). Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody can be used in WB.
Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody
Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody
😃Good
Catalog No. TMAB-11188
Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PSD93 (Tyr340). Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PSD93 (Tyr340). Anti-Phospho-PSD93 (Tyr340) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Concentrated in soma and postsynaptic density of a subset of neurons. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human PSD93 around the phosphorylation site of Tyr340 |
| Antigen Species | Human |
| Gene Name | DLG2 |
| Gene ID | |
| Protein Name | Disks large homolog 2 |
| Uniprot ID | |
| Function | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. |
| Molecular Weight | Theoretical: 98 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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