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1H-pyrazole

Name: 1H-pyrazole
Brand: TargetMol
SKU: T4842
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4842Cas No. 288-13-1

Alias Pyrazole, 1,2-Diazole

1H-pyrazole (1,2-Diazole), is a versatile building block, with a vast applications in organic synthesis. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.

1H-pyrazole

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Purity: 99.83%

Catalog No. T4842Alias Pyrazole, 1,2-DiazoleCas No. 288-13-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.83%

Appearance:Viscous

Color:White

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COA LCMS HNMR

Product Introduction

1H-pyrazole AI Summary

1H-pyrazole demonstrates a broad range of biological activities. It shows inhibitory activity against horse liver alcohol dehydrogenase (ADH) with a Ki value of 1862.09 nM and an IC50 value of 9800.0 nM against Sprague-Dawley rat cytosolic alcohol dehydrogenase. It also inhibits Thromboxane synthetase at a concentration of 100 µM with an 8.9% inhibition rate. The compound exhibits growth inhibition across various human tumor cell lines, including renal, breast, non-small cell lung, leukemia, central nervous system, melanoma, ovarian, prostate, and colon cancer cell lines, with a GI50 of 10000.0 nM, indicating significant potency. Additionally, 1H-pyrazole hinders the KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK, exceeding an IC50 and Ki value of 200000.0 nM, and it has a pKa value of 2.52, revealing its acidic nature. The compound also has a partition coefficient (logP) of 0.26, indicating it is mildly hydrophobic, and shows reversible inhibition of horse liver ADH using ethanol as a substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1H-pyrazole (1,2-Diazole), is a versatile building block, with a vast applications in organic synthesis. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.
Synonyms	Pyrazole, 1,2-Diazole

Chemical Properties

Molecular Weight	68.08
Formula	C₃H₄N₂
Cas No.	288-13-1
Smiles	N1C=CC=N1
Relative Density.	1.4088 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (734.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (29.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	14.6886 mL	73.4430 mL	146.8860 mL	734.4301 mL
5 mM	2.9377 mL	14.6886 mL	29.3772 mL	146.8860 mL
10 mM	1.4689 mL	7.3443 mL	14.6886 mL	73.4430 mL
20 mM	0.7344 mL	3.6722 mL	7.3443 mL	36.7215 mL
50 mM	0.2938 mL	1.4689 mL	2.9377 mL	14.6886 mL
100 mM	0.1469 mL	0.7344 mL	1.4689 mL	7.3443 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc