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(S,R,S)-AHPC-C4-NH2 hydrochloride (Alias: VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 l...)

Name: (S,R,S)-AHPC-C4-NH2 hydrochloride
Brand: TargetMol
SKU: T18640
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T18640 Copy Product Info

Purity: 99.57%

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(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.

(S,R,S)-AHPC-C4-NH2 hydrochloride

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Catalog No. T18640

Alias VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28

(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.

Cas No. 2245697-83-8

Pack Size	Price	USA Stock	Global Stock
5 mg	$32	-	In Stock
10 mg	$39	-	In Stock
25 mg	$64	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:Cyan

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
In vitro	PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1].
Synonyms	VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28

Chemical Properties

Molecular Weight	566.16
Formula	C₂₇H₄₀ClN₅O₄S
Cas No.	2245697-83-8
Smiles	CC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)ncs1)=O)=O)NC(CCCCN)=O.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (88.31 mM), Sonication is recommended.

DMSO: 109.6 mg/mL (193.58 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7663 mL	8.8314 mL	17.6629 mL	88.3143 mL
5 mM	0.3533 mL	1.7663 mL	3.5326 mL	17.6629 mL
10 mM	0.1766 mL	0.8831 mL	1.7663 mL	8.8314 mL
20 mM	0.0883 mL	0.4416 mL	0.8831 mL	4.4157 mL
50 mM	0.0353 mL	0.1766 mL	0.3533 mL	1.7663 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0177 mL	0.0883 mL	0.1766 mL	0.8831 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VHLVH032-C4-NH2 HydrochlorideLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 Ligase Ligand-Linker ConjugatesAHPC-C4-NH2 Hydrochloride(S,R,S)AHPCC4NH2 hydrochloride(S,R,S) AHPC C4 NH2 hydrochloride

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