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(S,R,S)-AHPC-C4-NH2 hydrochloride

🥰Excellent
Catalog No. T18640Cas No. 2245697-83-8
Alias VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28

(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.

(S,R,S)-AHPC-C4-NH2 hydrochloride
Other Forms of (S,R,S)-AHPC-C4-NH2 hydrochloride:

(S,R,S)-AHPC-C4-NH2 hydrochloride

🥰Excellent
Purity: 95.05%
Catalog No. T18640Alias VHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28Cas No. 2245697-83-8
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$32-In Stock
10 mg$39-In Stock
25 mg$64-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.05%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate comprising the (S,R,S)-AHPC-based VHL ligand and a linker.
In vitro
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1].
SynonymsVHL Ligand-Linker Conjugates 13, VH032-C4-NH2 hydrochloride, E3 ligase Ligand-Linker Conjugates 28
Chemical Properties
Molecular Weight566.16
FormulaC27H40ClN5O4S
Cas No.2245697-83-8
SmilesCC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)ncs1)=O)=O)NC(CCCCN)=O.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 50 mg/mL (88.31 mM), Sonication is recommended.
DMSO: 109.6 mg/mL (193.58 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.7663 mL8.8314 mL17.6629 mL88.3143 mL
5 mM0.3533 mL1.7663 mL3.5326 mL17.6629 mL
10 mM0.1766 mL0.8831 mL1.7663 mL8.8314 mL
20 mM0.0883 mL0.4416 mL0.8831 mL4.4157 mL
50 mM0.0353 mL0.1766 mL0.3533 mL1.7663 mL
DMSO
1mg5mg10mg50mg
100 mM0.0177 mL0.0883 mL0.1766 mL0.8831 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

VHLVH032-C4-NH2 HydrochlorideLigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 Ligase Ligand-Linker ConjugatesAHPC-C4-NH2 Hydrochloride(S,R,S)AHPCC4NH2 hydrochloride(S,R,S) AHPC C4 NH2 hydrochloride
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