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IDO1/TDO-IN-4
🥰Excellent
Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
IDO1/TDO-IN-4
🥰Excellent
Purity: 98.88%
Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock | |
| 5 mg | $112 | In Stock | |
| 10 mg | $187 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $119 | In Stock |
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Purity:98.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research. |
| Targets&IC50 | IDO1:3.53 μM, TDO:1.15 μM |
| In vitro | IDO1/TDO-IN-4 has dual inhibition on IDO1 and TDO with IC50 values of 3.53 μM and 1.15 μM, respectively. IDO1/TDO-IN-4 (0-2 μM, 1 h) can inhibit the activity of BV2 microglia induced by LPS. [1] |
| In vivo | IDO1/TDO-IN-4 (20 mg/kg) also salvaged lipopolysaccharids-induced depression-like behavior IN mice. [1] |
| Molecular Weight | 234.26 |
| Formula | C14H10N4 |
| Cas No. | 461424-21-5 |
| Smiles | N1=CNC(=C1)C=2N=CC=C3C4=CC=CC=C4NC23 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (426.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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