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IDO1/TDO-IN-4
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Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
IDO1/TDO-IN-4
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Purity: 98.88%
Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $43 | - | In Stock | |
| 5 mg | $106 | - | In Stock | |
| 10 mg | $187 | - | In Stock | |
| 25 mg | $313 | - | In Stock | |
| 50 mg | $463 | - | In Stock | |
| 100 mg | $679 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.88%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research. |
| Targets&IC50 | TDO:1.15 μM, IDO1:3.53 μM |
| In vitro | IDO1/TDO-IN-4 has dual inhibition on IDO1 and TDO with IC50 values of 3.53 μM and 1.15 μM, respectively. IDO1/TDO-IN-4 (0-2 μM, 1 h) can inhibit the activity of BV2 microglia induced by LPS. [1] |
| In vivo | IDO1/TDO-IN-4 (20 mg/kg) also salvaged lipopolysaccharids-induced depression-like behavior IN mice. [1] |
| Molecular Weight | 234.26 |
| Formula | C14H10N4 |
| Cas No. | 461424-21-5 |
| Smiles | N1=CNC(=C1)C=2N=CC=C3C4=CC=CC=C4NC23 |
| Storage | store at low temperature,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (426.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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