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DTS-201 sodium
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Catalog No. T203335Cas No. 372491-73-1
DTS-201 sodium (CPI-0004Na) is a peptide prodrug of Doxorubicin. It contains a tetrapeptide segment that is hydrolyzed by endopeptidases in the tumor microenvironment to produce metabolites, which are then converted into active Doxorubicin upon cellular entry. DTS-201 has demonstrated antitumor efficacy in xenograft models of prostate, breast, and lung cancers.
DTS-201 sodium
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Catalog No. T203335Cas No. 372491-73-1
DTS-201 sodium (CPI-0004Na) is a peptide prodrug of Doxorubicin. It contains a tetrapeptide segment that is hydrolyzed by endopeptidases in the tumor microenvironment to produce metabolites, which are then converted into active Doxorubicin upon cellular entry. DTS-201 has demonstrated antitumor efficacy in xenograft models of prostate, breast, and lung cancers.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DTS-201 sodium (CPI-0004Na) is a peptide prodrug of Doxorubicin. It contains a tetrapeptide segment that is hydrolyzed by endopeptidases in the tumor microenvironment to produce metabolites, which are then converted into active Doxorubicin upon cellular entry. DTS-201 has demonstrated antitumor efficacy in xenograft models of prostate, breast, and lung cancers. |
| In vivo | DTS-201 sodium shows good tolerance in mice (40-100 mg/kg), rats (30-70 mg/kg), and dogs (4-8 mg/kg) when administered intravenously over 15 minutes. On days 1 and 22, a single intravenous injection of DTS-201 sodium is well tolerated in mice (50 mg/kg, MTD) and rats (40 mg/kg, MTD). Administered weekly for seven weeks at doses of 3.2, 12.8, and 25.6 mg/kg, DTS-201 sodium exhibits significantly less cardiac toxicity than Doxorubicin, maintaining an average total score of ≤0.3, regardless of the dose. In xenograft mice models NCI-H1299, PC-3, and MDA-MB-231, intravenous DTS-201 sodium (40-80 mg/kg) demonstrates a better therapeutic index compared to free Doxorubicin. |
| Molecular Weight | 1034.05 |
| Formula | C49H64N5NaO18 |
| Cas No. | 372491-73-1 |
| Smiles | OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC(CCNC(CCC([O-])=O)=O)=O)=O)=O)=O)=C1C[C@](O)(C4)C(CO)=O.[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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