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TRPM4-IN-2

Name: TRPM4-IN-2
Brand: TargetMol
SKU: T61275
Rating: 4.5 (1 reviews)

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Catalog No. T61275Cas No. 667411-04-3

Alias NBA

TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2].

TRPM4-IN-2

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Purity: 99.21%

Catalog No. T61275Alias NBACas No. 667411-04-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	Inquiry	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2].
Targets&IC50	TRPM4:0.16 μM
In vitro	TRPM4-IN-2 (NBA) at a concentration of 50 μM blocked 88 ± 9% of endogenous TRPM4 currents within 500 seconds.
Synonyms	NBA

Chemical Properties

Molecular Weight	355.77
Formula	C₁₉H₁₄ClNO₄
Cas No.	667411-04-3
Smiles	O(CC(NC1=C(C(O)=O)C=CC(Cl)=C1)=O)C=2C3=C(C=CC2)C=CC=C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (252.97 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8108 mL	14.0540 mL	28.1080 mL	140.5402 mL
5 mM	0.5622 mL	2.8108 mL	5.6216 mL	28.1080 mL
10 mM	0.2811 mL	1.4054 mL	2.8108 mL	14.0540 mL
20 mM	0.1405 mL	0.7027 mL	1.4054 mL	7.0270 mL
50 mM	0.0562 mL	0.2811 mL	0.5622 mL	2.8108 mL
100 mM	0.0281 mL	0.1405 mL	0.2811 mL	1.4054 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc