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TargetMol | Compound Library

Fluorochemical Library

Catalog No. L5100

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances. The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved >140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc. The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties. Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol's fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5100

Fluorochemical Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2684 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are in stock.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Apoptosis
Autophagy
5-HT Receptor
Antibacterial
VEGFR
Antibiotic
EGFR
Dehydrogenase
PI3K
Dopamine Receptor
DNA/RNA Synthesis
Raf
Potassium Channel
Sodium Channel
Antifungal
CDK
COX
FLT
HIV Protease
p38 MAPK
c-Met/HGFR
Parasite
TRP/TRPV Channel
PDGFR
GluR
Calcium Channel
PDE
c-Kit
Bcr-Abl
Glucocorticoid Receptor
Src
JAK
Epigenetic Reader Domain
Androgen Receptor
GPR
Prostaglandin Receptor
Histone Methyltransferase
HCV Protease
Adrenergic Receptor
GABA Receptor
AChR
PARP
Aurora Kinase
SARS-CoV
Phospholipase
MEK
Nucleoside Antimetabolite/Analog
FGFR
CCR
mTOR
PPAR
Topoisomerase
Cytochromes P450
MAPK
HBV
c-RET
TAM Receptor
Histamine Receptor
Gamma-secretase
Trk receptor
HDAC
Microtubule Associated
ERK
iGluR
DUB
Antiviral
Proteasome
ROR
Estrogen/progestogen Receptor
Phosphatase
Tyrosine Kinases
Akt
Influenza Virus
S6 Kinase
Reductase
GSK-3
Wnt/beta-catenin
NMDAR
ALK
Casein Kinase
STAT
Kras
YAP
Virus Protease
Cysteine Protease
Caspase
IL Receptor
Ras
CFTR
HER
Proton pump
Adenosine Receptor
Estrogen Receptor/ERR
PKC
ROCK
Glucagon Receptor
Guanylate cyclase
CXCR
Histone Acetyltransferase
IκB/IKK
NF-κB
PLK
HIF
Discoidin Domain Receptor (DDR)
Neurokinin receptor
FAK
S1P Receptor
LPL Receptor
CETP
MAO
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Isocitrate Dehydrogenase (IDH)
DPP-4
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Indoleamine 2,3-Dioxygenase (IDO)
TGF-beta/Smad
HSP
STING
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TNF
Cannabinoid Receptor
HMG-CoA Reductase
Mdm2
Ferroptosis
BACE
Mitophagy
Rho
Serotonin Transporter
Liver X Receptor
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P2X Receptor
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transporter
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Syk
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PKA
Pim
Glucokinase
CSF-1R
Mitochondrial Metabolism
Smo
Chk
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Acyltransferase
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TLR
Sigma receptor
Kinesin
Monoamine Oxidase
Melanin-concentrating Hormone Receptor (MCHR)
NOS
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cAMP
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LTR
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