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Anti-APAF1 (CT) Polyclonal Antibody

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Catalog No. TMAB-02727

Anti-APAF1 (CT) Polyclonal Antibody is a Rabbit antibody targeting APAF1 (CT). Anti-APAF1 (CT) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.

Anti-APAF1 (CT) Polyclonal Antibody

Anti-APAF1 (CT) Polyclonal Antibody

😃Good
Catalog No. TMAB-02727
Anti-APAF1 (CT) Polyclonal Antibody is a Rabbit antibody targeting APAF1 (CT). Anti-APAF1 (CT) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-APAF1 (CT) Polyclonal Antibody is a Rabbit antibody targeting APAF1 (CT). Anti-APAF1 (CT) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
Reactivity
Human,Rat (predicted:Mouse,Dog,Horse,Danio rerio)
Application
IHC-P
IHC-Fr
ICC/IF
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm.
Tissue SpecificityUbiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Apaf-1
Antigen Species
Human
Gene Name
APAF1
Gene ID
317
Protein Name
Apoptotic protease-activating factor 1
Uniprot ID
O14727
Function
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Chemical Properties
Molecular WeightTheoretical: 137 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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