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TOPBioactivityRelated Conjugates and FormulationsAntigen DetailsChemical infoStorage&SolubilityCalculator

Anti-ADAR Antibody (6K725)

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Catalog No. TMAC-00088

Anti-ADAR Antibody (6K725) is a Rabbit antibody targeting ADAR. Anti-ADAR Antibody (6K725) can be used in ICC,IF,IHC,WB.

Anti-ADAR Antibody (6K725)

Anti-ADAR Antibody (6K725)

😃Good
Catalog No. TMAC-00088
Anti-ADAR Antibody (6K725) is a Rabbit antibody targeting ADAR. Anti-ADAR Antibody (6K725) can be used in ICC,IF,IHC,WB.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-ADAR Antibody (6K725) is a Rabbit antibody targeting ADAR. Anti-ADAR Antibody (6K725) can be used in ICC,IF,IHC,WB.
Ig Type
IgG
Clone
6K725
Reactivity
Human
Verified Activity
1. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ADAR antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ADAR antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-ADAR antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-ADAR antibody. Counter stained with hematoxylin.
5. ICC staining ADAR in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Western blot analysis of ADAR1 expression in Ramos cell lysate.
Application
ICC
IF
IHC
WB
Recommended Dose
WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundRNA-specific adenosine deaminase (ADAR1, DSH, IFI4, p136, DRADA, DSRAD, K88dsRBP) mediates RNA editing by destabilizing double stranded RNA through deamination of adenosine to inosine in structured or double-stranded RNAs. ADAR1 is expressed from an interferon-response promoter and has a Z-DNA/Z-RNA binding domain at its N-terminus. ADAR1 co-localizes with SUMO-1 in a subnucleolar region that is distinct from the fibrillar center, the dense fibrillar component and the granular component. Localization of nuclear ADAR1 is under the influence of a nucleolar localization signal (NoLS) in the middle of ADAR1 and the exporting activity of the nuclear exporter signal (NES) near the N terminus. ADAR1 upregulates nuclear factor 90 (NF90)-mediated gene expression by interacting with NF110, NF90 and NF45. ADAR1 binds short interfering RNA (siRNA), and gene silencing by siRNA is significantly more effective in mouse fibroblasts homozygous for an ADAR1 null mutation than in wild-type cells. ADAR1 may limit the efficacy of siRNA in mammalian cells.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
P55265
Chemical Properties
Molecular WeightTheoretical: 150 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p136K88DSRBPInterferon-inducible protein 4 (IFI-4)IFI-4IFI4IFI 4G1P1G1P 1DSRADDRADADouble-stranded RNA-specific adenosine deaminaseADAR1ADAR 1ADAR136 kDa double-stranded RNA-binding protein (p136)
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