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Tipifarnib (S enantiomer)

Name: Tipifarnib (S enantiomer)
Brand: TargetMol
SKU: T17102
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17102Cas No. 192185-71-0

Alias Tipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777

Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).

Tipifarnib (S enantiomer)

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Purity: 99.05%

Catalog No. T17102Alias Tipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777Cas No. 192185-71-0

Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$109	In Stock	In Stock
10 mg	$175	In Stock	In Stock
25 mg	$316	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$642	-	In Stock
200 mg	$865	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.05%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Tipifarnib (S enantiomer) AI Summary

Tipifarnib (S enantiomer) exhibits bioactivity as a potent inhibitor of FTase, demonstrating an IC50 value of 0.9 nM and an EC50 value of 1.8 nM. FTase is an important enzyme involved in the post-translational modification of proteins. Additionally, Tipifarnib (S enantiomer) shows low activity in inhibiting Trypanosoma cruzi recombinant sterol 14-alpha-demethylase with an activity value of 0.74. However, it exhibits a high level of inhibition against human sterol 14-alpha-demethylase, with an activity greater than 100.0..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
Synonyms	Tipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777

Chemical Properties

Molecular Weight	489.4
Formula	C₂₇H₂₂Cl₂N₄O
Cas No.	192185-71-0
Smiles	Cn1cncc1[C@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (51.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0433 mL	10.2166 mL	20.4332 mL	102.1659 mL
5 mM	0.4087 mL	2.0433 mL	4.0866 mL	20.4332 mL
10 mM	0.2043 mL	1.0217 mL	2.0433 mL	10.2166 mL
20 mM	0.1022 mL	0.5108 mL	1.0217 mL	5.1083 mL
50 mM	0.0409 mL	0.2043 mL	0.4087 mL	2.0433 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc