Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK717 is a potent and selective inhibitor of nucleotide-binding oligomerization domain 2 (NOD2). GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 269.00 | |
50 mg | In stock | $ 452.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | GSK717 is a potent and selective inhibitor of nucleotide-binding oligomerization domain 2 (NOD2). GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. |
In vitro | GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. |
Molecular Weight | 452.55 |
Formula | C28H28N4O2 |
CAS No. | 1595278-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (552.43 mM)
You can also refer to dose conversion for different animals. More
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GSK717 1595278-21-9 Immunology/Inflammation NF-Κb NOD IL Receptor GSK 717 immune inhibit Inhibitor GSK-717 NOD2-TLR2 pro-inflammatory MDP-stimulated NOD-like Receptor (NLR) responses cytokines synergy inhibitor