IL-18R alpha Protein, Human, Recombinant (His), Biotinylated

IL-18R alpha Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.21 kDa and the accession number is NP_003846.1.

Pack Size	Availability	Price/USD	Quantity
20 μg	5 days	$ 498.00
100 μg	5 days	$ 1,190.00

Pack Size

Availability

Price/USD

Quantity

20 μg

5 days

$ 498.00

100 μg

5 days

$ 1,190.00

Description

IL-18R alpha Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.21 kDa and the accession number is NP_003846.1.

Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	NP_003846.1
Synonyms	IL18RA, interleukin 18 receptor 1, IL1RRP, CDw218a, CD218a, IL-1Rrp
Construction	The Human IL18R1 (NP_003846.1) (Met1-Arg329) was expressed, fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Molecular Weight	37.21 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.