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S-(2-aminoethyl) Isothiourea (dihydrobromide)

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Catalog No. T7543Cas No. 56-10-0

S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively

S-(2-aminoethyl) Isothiourea (dihydrobromide)

S-(2-aminoethyl) Isothiourea (dihydrobromide)

🥰Excellent
Purity: 99.77%
Catalog No. T7543Cas No. 56-10-0
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 g$34-In Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.77%
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Product Introduction

Bioactivity
Description
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively
Targets&IC50
iNOS:0.59 µM, nNOS:1.8 µM , eNOS:2.1 µM
Chemical Properties
Molecular Weight281.02
FormulaC3H11Br2N3S
Cas No.56-10-0
SmilesBr.Br.NCCSC(N)=N
Relative Density.1.94 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (106.75 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5585 mL17.7923 mL35.5847 mL177.9233 mL
5 mM0.7117 mL3.5585 mL7.1169 mL35.5847 mL
10 mM0.3558 mL1.7792 mL3.5585 mL17.7923 mL
20 mM0.1779 mL0.8896 mL1.7792 mL8.8962 mL
50 mM0.0712 mL0.3558 mL0.7117 mL3.5585 mL
100 mM0.0356 mL0.1779 mL0.3558 mL1.7792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S(2aminoethyl) Isothiourea (dihydrobromide)S-(2-aminoethyl) IsothioureaS (2 aminoethyl) Isothiourea (dihydrobromide)NOS
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