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S-(2-aminoethyl) Isothiourea (dihydrobromide)
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Catalog No. T7543Cas No. 56-10-0
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively
S-(2-aminoethyl) Isothiourea (dihydrobromide)
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Purity: 99.77%
Catalog No. T7543Cas No. 56-10-0
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 g | $34 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.77%
Appearance:Solid
Color:White
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Product Introduction
S-(2-aminoethyl) Isothiourea (dihydrobromide) AI Summary
S-(2-aminoethyl) Isothiourea (dihydrobromide) exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 10000.0 nM to 15848.93 nM after 72 hours by SYBR green assay. Additionally, it shows a wide range of bioactivities including potent inhibitory effects on histone lysine methyltransferase G9a and Fructose-1,6-bisphosphate aldolase from Giardia Lamblia. The compound also inhibits Tau fibril formation and affects the proliferation of various Plasmodium falciparum lines. Furthermore, S-(2-aminoethyl) Isothiourea (dihydrobromide) influences genomic imprints and SMN2 splice variant expression, serves as a potential activator of Cytochrome P450 3A4, and inhibits Mammalian Selenoprotein Thioredoxin Reductase 1..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 μM, respectively |
| Targets&IC50 | nNOS:1.8 µM , eNOS:2.1 µM , iNOS:0.59 µM |
| Molecular Weight | 281.02 |
| Formula | C3H11Br2N3S |
| Cas No. | 56-10-0 |
| Smiles | Br.Br.NCCSC(N)=N |
| Relative Density. | 1.94 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (106.75 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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