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Rp-cAMPS triethylammonium salt

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Catalog No. T12764Cas No. 151837-09-1

Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.

Rp-cAMPS triethylammonium salt
Other Forms of Rp-cAMPS triethylammonium salt:

Rp-cAMPS triethylammonium salt

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Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$28935 days35 days
1 mg$48935 days35 days
5 mg$2,05835 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Targets&IC50
PKA II:4.5 µM (Ki), PKA I:12.5 µM (Ki)
In vitro
Rp-cAMPS triethylammonium salt inhibits CAMP-induced CAMP-dependent protein kinase I and II activation with Ki values of 12.5 µM and 4.5 µM.
Rp-cAMPS triethylammonium salt (100 μM) reduced K+ current induced by calcitonin gene-related peptide (CGRP) in porcine smooth muscle cells. [2]
In vivo
Rp-cAMPS triethylammonium salt (10 μM, 15 min) reduced monosynaptic EPSCs of PB-CeLC and BLA-CeLC synapses in arthritic rats, but had no effect on control neurons in normal animals. [1]
Intrabla infusion of Rp-cAMPS triethylammonium salt after cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory-reactivation dependent manner. [3]
Chemical Properties
Molecular Weight446.46
FormulaC16H27N6O5PS
Cas No.151837-09-1
SmilesN(CC)(CC)CC.O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@]4([C@]1(OP(=O)(S)OC4)[H])[H]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8 mg/mL (17.92 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2398 mL11.1992 mL22.3984 mL111.9921 mL
5 mM0.4480 mL2.2398 mL4.4797 mL22.3984 mL
10 mM0.2240 mL1.1199 mL2.2398 mL11.1992 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

RpcAMPS triethylammonium saltRp-cAMPS triethylammoniumRp cAMPS triethylammonium saltPKA IIPKA I
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