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Rp-cAMPS triethylammonium salt

Name: Rp-cAMPS triethylammonium salt
Brand: TargetMol
SKU: T12764
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.

Cas No. 151837-09-1

Pack Size	Price	USA Stock	Global Stock	Quantity
500 µg	$147	-	In Stock
1 mg	$237	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Targets & IC50	PKA I:12.5 µM (Ki), PKA II:4.5 µM (Ki)
In vitro	Rp-cAMPS triethylammonium salt inhibits CAMP-induced CAMP-dependent protein kinase I and II activation with Ki values of 12.5 µM and 4.5 µM. Rp-cAMPS triethylammonium salt (100 μM) reduced K+ current induced by calcitonin gene-related peptide (CGRP) in porcine smooth muscle cells. [2]
In vivo	Rp-cAMPS triethylammonium salt (10 μM, 15 min) reduced monosynaptic EPSCs of PB-CeLC and BLA-CeLC synapses in arthritic rats, but had no effect on control neurons in normal animals. [1] Intrabla infusion of Rp-cAMPS triethylammonium salt after cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory-reactivation dependent manner. [3]

Chemical Properties

Molecular Weight	446.46
Formula	C₁₆H₂₇N₆O₅PS
Cas No.	151837-09-1
Smiles	N(CC)(CC)CC.O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@]4([C@]1(OP(=O)(S)OC4)[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (17.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2398 mL	11.1992 mL	22.3984 mL	111.9921 mL
5 mM	0.4480 mL	2.2398 mL	4.4797 mL	22.3984 mL
10 mM	0.2240 mL	1.1199 mL	2.2398 mL	11.1992 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RpcAMPS triethylammonium saltRp-cAMPS triethylammoniumRp cAMPS triethylammonium saltPKA IIPKA I

Related Tags: Rp-cAMPS triethylammonium salt chemical structure | Rp-cAMPS triethylammonium salt in vivo | Rp-cAMPS triethylammonium salt in vitro | Rp-cAMPS triethylammonium salt formula | Rp-cAMPS triethylammonium salt molecular weight