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Rp-cAMPS triethylammonium salt

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Catalog No. T12764Cas No. 151837-09-1

Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.

Rp-cAMPS triethylammonium salt
Other Forms of Rp-cAMPS triethylammonium salt:

Rp-cAMPS triethylammonium salt

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Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$289-In Stock
1 mg$455-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Targets&IC50
PKA I:12.5 µM (Ki), PKA II:4.5 µM (Ki)
In vitro
Rp-cAMPS triethylammonium salt inhibits CAMP-induced CAMP-dependent protein kinase I and II activation with Ki values of 12.5 µM and 4.5 µM.
Rp-cAMPS triethylammonium salt (100 μM) reduced K+ current induced by calcitonin gene-related peptide (CGRP) in porcine smooth muscle cells. [2]
In vivo
Rp-cAMPS triethylammonium salt (10 μM, 15 min) reduced monosynaptic EPSCs of PB-CeLC and BLA-CeLC synapses in arthritic rats, but had no effect on control neurons in normal animals. [1]
Intrabla infusion of Rp-cAMPS triethylammonium salt after cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory-reactivation dependent manner. [3]
Chemical Properties
Molecular Weight446.46
FormulaC16H27N6O5PS
Cas No.151837-09-1
SmilesN(CC)(CC)CC.O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@]4([C@]1(OP(=O)(S)OC4)[H])[H]
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8 mg/mL (17.92 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2398 mL11.1992 mL22.3984 mL111.9921 mL
5 mM0.4480 mL2.2398 mL4.4797 mL22.3984 mL
10 mM0.2240 mL1.1199 mL2.2398 mL11.1992 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RpcAMPS triethylammonium saltRp-cAMPS triethylammoniumRp cAMPS triethylammonium saltPKA IIPKA I
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