Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BACE1/2-IN-1 in liver microsomes is decreased.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BACE1/2-IN-1 in liver microsomes is decreased. |
In vitro | Compound 34, identified as BACE1/2-IN-1, exhibits a modest preference for BACE2 over BACE1, while maintaining a selectivity greater than 3000-fold when compared to Cathepsin D [1]. |
In vivo | BACE1/2-IN-1 (compound 34) administered through subcutaneous injection at doses of 0-100 mg/kg once in PDAPP (V717F) transgenic mice, significantly reduces cortical Aβ levels by 40% at 100 mg/kg and 24% at 30 mg/kg, with no significant reduction (12%NS) observed at 10 mg/kg [1]. |
Molecular Weight | 401.57 |
Formula | C21H31N5OS |
CAS No. | 2671036-34-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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BACE1/2-IN-1 2671036-34-1 inhibitor inhibit