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BACE1/2-IN-1

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Catalog No. T61956Cas No. 2671036-34-1

BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 μM, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes.

BACE1/2-IN-1

BACE1/2-IN-1

😃Good
Catalog No. T61956Cas No. 2671036-34-1
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 μM, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 μM, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes.
In vitro
Compound 34, identified as BACE1/2-IN-1, exhibits a modest preference for BACE2 over BACE1, while maintaining a selectivity greater than 3000-fold when compared to Cathepsin D [1].
In vivo
Administered subcutaneously at doses of 0-100 mg/kg in PDAPP (V717F) transgenic mice, BACE1/2-IN-1 (compound 34) significantly reduces cortical Aβ levels by 40% at 100 mg/kg and 24% at 30 mg/kg, with no significant reduction (12%NS) observed at 10 mg/kg [1].
Chemical Properties
Molecular Weight401.57
FormulaC21H31N5OS
Cas No.2671036-34-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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