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KR-32568

Name: KR-32568
Brand: TargetMol
SKU: T36569
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36569Cas No. 852146-73-7

KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM) with potent cardioprotective effects. At a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. Additionally, KR-32568 (0.3 mg/kg) reduced myocardial infarction size in a rat model of ischemia and reperfusion injury.

KR-32568

🥰Excellent

Purity: 99.89%

Catalog No. T36569Cas No. 852146-73-7

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$93	In Stock
10 mg	$148	In Stock
25 mg	$298	In Stock
50 mg	$433	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM) with potent cardioprotective effects. At a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. Additionally, KR-32568 (0.3 mg/kg) reduced myocardial infarction size in a rat model of ischemia and reperfusion injury.
Targets&IC50	NHE1:230 nM
In vitro	KR-32568 (10 nM-1 μM) inhibited NHE-1-mediated platelet swelling induced by intracellular acidification in rabbit platelet-rich plasma in a concentration-dependent manner, with an IC50 value of 24 nM.[1]
In vivo	KR-32568 (0.1-1.0 mg/kg; i.v.; once) exerts effective cardioprotective effects in rats, such as reducing infarct size and significantly reducing the total number of premature ventricular contractions.[1]

Chemical Properties

Molecular Weight	261.25
Formula	C₁₃H₁₂FN₃O₂
Cas No.	852146-73-7
Smiles	CC1=C(C=2OC(C(NC(=N)N)=O)=CC2)C=C(F)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (344.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8278 mL	19.1388 mL	38.2775 mL	191.3876 mL
5 mM	0.7656 mL	3.8278 mL	7.6555 mL	38.2775 mL
10 mM	0.3828 mL	1.9139 mL	3.8278 mL	19.1388 mL
20 mM	0.1914 mL	0.9569 mL	1.9139 mL	9.5694 mL
50 mM	0.0766 mL	0.3828 mL	0.7656 mL	3.8278 mL
100 mM	0.0383 mL	0.1914 mL	0.3828 mL	1.9139 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc